Promoter Hypermethylation in Benign Breast Epithelium in Relation to Predicted Breast Cancer Risk

Abstract

Since cyclin D2 promoter methylation occurs almost exclusively in tumors, it may be possible to exploit it for the early detection of breast cancer. Promoter methylation of APC, RARbeta2, and RASSF1A in benign breast epithelium is associated with epidemiologic markers of increased breast cancer risk.