Oridonin Up-regulates Expression of <i>P21</i> and Induces Autophagy and Apoptosis in Human Prostate Cancer Cells

Abstract

Our findings indicated that autophagy occurred before the onset of apoptosis and protected cancer cells in ORI-treated HPC cells. P21 was involved in ORI-induced autophagy and apoptosis. Our results provide an experimental basis for understand the anti-tumor mechanism of ORI as treatment for prostate cancer.