A Foreign Body Granuloma Produced by an Injectable Collagen Implant at a Test Site

Abstract

Zyderm collagen implant, a solubilized, purified, bovine collagen preparation for augmentation of soft tissue, produced a foreign body granuloma in a 37-year-old woman who had no history of immunologic disorders or autoimmune disease. The patient had received a small test implant to determine if she were sensitive to Zyderm. A very slight, borderline response occurred and a second test implant was administered. This second implant resulted in a foreign body granuloma that has persisted for ten months.