Cleft palate defect of <i>Dlx1/2</i>−/− mutant mice is caused by lack of vertical outgrowth in the posterior palate

Abstract

The functions of Dlx1 and Dlx2 are crucial for the initial formation of the posterior palatal shelves, and that the Dlx genes lie upstream of multiple signaling molecules and transcription factors important for later stages of palatogenesis.