Organic Letters · 2011 · 44 citations · 30 references
Natural SciencesChemistryAnalytical ChemistryOrganic ChemistrySpectroscopyChiral RecognitionCircular Dichroism SpectroscopyHeterocyclic ChemistryCalibration Curve AnalysisChirality DeterminationCircular DichroismCircular Dichroism AnalysisEnantiomeric Excess MeasurementEnantioselective DetectionHigh-throughput Screening AssaysMetal-ligand Charge Transfer
Ketone handedness was discriminated using circular dichroism (CD) spectroscopy by monitoring the metal-to-ligand charge transfer (MLCT) bands of complexes between [Cu(I)((S)-1)(CH(3)CN)(2)]PF(6) and derivatized α-chiral cyclohexanones (4). This method was able to quantify the enantiomeric excess of unknown samples using a calibration curve, giving an absolute error of ±7%. The analysis was fast, allowing potential application of this assay in high-throughput screening (HTS).
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