Role of N-Methyl-N-nitrosourea in the Induction of Intestinal Metaplasia and Gastric Adenocarcinoma in Mongolian Gerbils Infected with Helicobacter pylori

Abstract

Intestinal metaplasia and adenocarcinoma arise in stomachs subjected to the same injuries (in this study, H. pylori and MNU). Only two intestinal-type carcinomas were contiguous to intestinal metaplasia; all other tumors developed most commonly at non-metaplastic sites. This suggests that in this animal model H. pylori and MNU induce several phenotypes of gastric cancer, but intestinal metaplasia may be a direct precursor only in a subset of the intestinal-type tumors.