Concepedia

Effects of F171 Mutations in the 6′- <i>N</i> -Acetyltransferase Type Ib [AAC(6′)-Ib] Enzyme on Susceptibility to Aminoglycosides

Ramona Chavideh, Steven Sholly, Doina Panaite, Marcelo E. Tolmasky

Antimicrobial Agents and Chemotherapy · 1999 · 16 citations · 16 references

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Concepts

Abstract

Substitutions at position F171 of 6'-N-acetyltransferase type Ib cause variable loss of aminoglycoside resistance, indicating that this residue plays an important role in the structure and/or function of the enzyme.

References

16

Antibacterial susceptibility tests : Dilution and disk diffusion methods.

Gl. Woods · Medical Entomology and Zoology · 1995 · 561 citations

, , +11

Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions

James U. Bowie, John F. Reidhaar-Olson, Wendell A. Lim et al. · Science · 1990 · 487 citations

, , +16

GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein

Andrew F. Neuwald · Trends in Biochemical Sciences · 1997 · 447 citations

, , +15

Crystal Structure of a GCN5-Related N-acetyltransferase

Eva Wolf, Alex Vassilev, Yasutaka Makino et al. · Cell · 1998 · 236 citations · Full text

, , +8

Crystal structure of an aminoglycoside 6′-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold

Leanne Wybenga-Groot, Kari-ann Draker, Gerard D. Wright et al. · Structure · 1999 · 139 citations · Full text

, , +9