Clinical, biochemical and imaging characteristics of Cushing's macroadenomas and their long‐term treatment outcome

Abstract

Younger age at presentation and larger tumour size compared with previous series were distinctive features of our series. Large tumour size and parasellar extension were negative predictors of surgical remission. Delayed remission was seen in significant proportion of patients, but one-third later relapsed. Radiotherapy was an effective second-line treatment modality.