Regioselective Diazo‐Transfer Reaction at the C3‐Position of the 2‐Desoxystreptamine Ring of Neamine Antibiotics

Abstract

Site-selective diazotation: A facile one-step modification at the 2-desoxystreptamine ring, is reported in diverse neamine antibiotics reaching high regioselectivities (see scheme; r.s.=regioselectivities). The diazo-transfer reaction takes place in aqueous solution, under mild conditions, and without any protective groups. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.