Prenatal search for UPD 14 and UPD 15 in 83 cases of familial and <i>de novo</i> heterologous Robertsonian translocations

Abstract

Our data, combined with other previous prenatal investigations provide a general risk estimate for UPD 14 and 15 of 0.6%. Nevertheless, combining our data and those previously reported, all three fetuses with UPD had a de novo Robertsonian translocation, thus suggesting a risk of UPD formation of about 3% for this specific group of translocation carriers.