Angewandte Chemie International Edition · 2005 · 31 citations · 30 references
Natural SciencesBiophysicsMolecular BiologyMolecular VirologyStructural BiologyVirologyElectrostatic Interactions In BiomoleculesIntermolecular InteractionsMolecular DynamicsNucleic Acid DynamicsRna BiophysicsRna StructureConformational Dynamics Of RnaElectrostatic InteractionsElectrostatic Interactions In Nucleic Acid BindingMolecular Electrostatics Of Nucleic AcidsNucleic Acid ElectrostaticsResidual Dipolar Coupling AnalysisResidual Dipolar CouplingsRna Structural Dynamics
The global dynamics of the TAR RNA from HIV-1 bound to two distinctly charged molecules have been characterized by NMR studies of residual dipolar couplings (see picture). While neomycin B (NeoB: +5) arrests global motions in TAR, the small organic molecule acetylpromazine (AcP: +1) does not. Results indicate that electrostatic interactions are critical for arresting global motions in RNA.
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Joel R. Tolman, John M. Flanagan, Michael A. Kennedy et al. · Proceedings of the National Academy of Sciences · 1995 · 836 citations · Full text
Conformation of the TAR RNA-Arginine Complex by NMR Spectroscopy
Joseph D. Puglisi, Ruoying Tan, Barbara J. Calnan et al. · Science · 1992 · 600 citations