American Journal on Addictions · 2009 · 131 citations · 19 references
PharmacyPharmacologyForensic ToxicologySubstance Abuse ToxicologySubstance Use DisordersDrug Overdose PreventionOpioid PolicyOpioid ToxicologyOverdose PreventionPharmacoepidemiologySubstance Abuse PreventionAdult PrevalenceDeath Rate AnalysisDrug Abuse EpidemiologyDrug Overdose MortalityDrug Overdose SurveillanceDrug Use EpidemiologyIllicit Drug DeathsOpioid-related Mortality
In rural Virginia, drug overdose deaths increased 300% from 1997 to 2003. Polydrug deaths predominate (57.9%) in this review of 893 medical examiner cases. Prescription opioids (74.0%), antidepressants (49.0%), and benzodiazepines (39.3%) were more prevalent than illicit drugs. Two-thirds of decedents were 35-54 years old; 37% were female. When compared to western Virginia metropolitan cases, polydrug abuse was more common, specific medication combinations were found, the death rate per population was higher, and fewer illicit drugs were detected. These rural prescription overdose deaths differ from urban illicit drug deaths, suggesting the need for different strategies in prevention, treatment, and intervention by clinicians and policymakers.
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Mechanisms of fatal opioid overdose
Jason M. White, Rodney J. Irvine · Addiction · 1999 · 626 citations
Medicine, Neuroscience, Pharmacology +16
Fentanyl Use, Misuse, and Abuse: A Summary of 23 Postmortem Cases
James J. Kuhlman, R.A. McCaulley, T. J. Valouch et al. · Journal of Analytical Toxicology · 2003 · 136 citations · Full text