Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol

Abstract

We have performed a major preclinical validation of a new method for PGS and found that the technology performs approximately as well as a metaphase karyotype. We also directly measured the mechanism of aneuploidy in cleavage-stage human embryos and found high rates and distinct patterns of mitotic and meiotic aneuploidy.