Monoclonal Antibody-Based Screening Assay for Factor Inhibiting Hypoxia-Inducible Factor Inhibitors

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O ₂ -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

Life Sciences, Biochemistry, Molecular Biology +17

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Hua Zhong, Angelo M. De Marzo, Erik Laughner et al. · PubMed · 1999 · 2.2K citations

Medicine, Cancer Biology, Oncology +14

Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

Eric Huang, Jie Gu, Maureen Schau et al. · Proceedings of the National Academy of Sciences · 1998 · 2.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

David Lando, Daniel J. Peet, Dean A. Whelan et al. · Science · 2002 · 1.5K citations

Life Sciences, Biochemistry, Molecular Biology +14

Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation

Joo‐Won Jeong, Moon-Kyoung Bae, Mee-Young Ahn et al. · Cell · 2002 · 720 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +7