Publication | Closed Access
The assignment of the genes coding for human complement components C6 and C7 to chromosome 5
24
Citations
19
References
1990
Year
EngineeringCytogeneticsGeneticsDna AnalysisMolecular GeneticsGenomicsImmune-related Gene PolymorphismGene StructureSomatic GeneticsDna SequencingHybridizationGenetic VariationGene ExpressionCell BiologyGene FunctionComplement SystemAllelic VariantSomatic Cell GeneticsGenetic EngineeringChromosome 5Restriction Enzyme DigestionSystems BiologyMedicineC7 Cdna Probes
A panel of 19 somatic cell hybrids was tested for the presence of human sequences coding for complement components C6 and C7 by restriction enzyme digestion and Southern blots probed with human C6 and C7 cDNA probes. C7 was also detected by amplifying part of the human gene in hybrid DNA using the polymerase chain reaction. Detection of human C6 and C7 was completely correlated with the presence of chromosome 5.
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