Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors

Abstract

Central myelinated axons express functional AMPA and GluR5 kainate receptors, and can directly respond to glutamate receptor agonists. These glutamate receptor-dependent signaling pathways promote an increase in intraaxonal Ca(2+) levels potentially contributing to axonal degeneration.