Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of Aβ peptides of Alzheimer's disease

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Colin L. Masters, G. Simms, Nicola A. Weinman et al. · Proceedings of the National Academy of Sciences · 1985 · 4.4K citations · Full text

Life Sciences, Biochemistry, Neurology +17

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

Christian J. Pike, Andrea J. Walencewicz, Charles Glabe et al. · Brain Research · 1991 · 827 citations

Life Sciences, Biochemistry, Neuroscience +16

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

Alex E. Roher, Jonathan D. Lowenson, Steven Clarke et al. · Journal of Biological Chemistry · 1993 · 799 citations · Full text

Life Sciences, Neurology, Neuroscience +17

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

Alex E. Roher, Jonathan D. Lowenson, Steven Clarke et al. · Proceedings of the National Academy of Sciences · 1993 · 742 citations

Life Sciences, Neurobiology, Neuroscience +17

Water-soluble Aβ(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains

Yu‐Min Kuo, Mark R. Emmerling, Carmen Vigo‐Pelfrey et al. · Journal of Biological Chemistry · 1996 · 616 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17