Concepedia

Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100

Rosie Z. Yu, Tae‐Won Kim, An Hong, Tanya Watanabe, Hans Gaus, Richard S. Geary

Drug Metabolism and Disposition · 2006 · 238 citations · 29 references

DOI

Concepts

References

29

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics

Harold Boxenbaum · Journal of Pharmacokinetics and Biopharmaceutics · 1982 · 646 citations

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Potent Reduction of Apolipoprotein B and Low-Density Lipoprotein Cholesterol by Short-Term Administration of an Antisense Inhibitor of Apolipoprotein B

John J.P. Kastelein, Mark K. Wedel, Brenda F. Baker et al. · Circulation · 2006 · 357 citations · Full text

, , +16

Pharmacokinetic Properties of 2′-O-(2-Methoxyethyl)-Modified Oligonucleotide Analogs in Rats

Richard S. Geary, Tanya Watanabe, L Truong et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 283 citations

, , +15

Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats.

Paul A. Cossum, Henri Sasmor, D Dellinger et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 266 citations

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A Phase I Pharmacokinetic and Pharmacodynamic Study of OGX-011, a 2′-Methoxyethyl Antisense Oligonucleotide to Clusterin, in Patients With Localized Prostate Cancer

Kim N., Elizabeth A. Eisenhauer, Ladan Fazli et al. · JNCI Journal of the National Cancer Institute · 2005 · 263 citations

, , +11