Identification of the Cytochrome P450 and Other Enzymes Involved in the In Vitro Oxidative Metabolism of a Novel Antidepressant, Lu AA21004

THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE

Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf et al. · Drug Metabolism and Disposition · 2003 · 784 citations

Medicine, Pharmacokinetics, Pharmacology +17

Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

Benny Bang‐Andersen, Thomas Ruhland, Morten Jørgensen et al. · Journal of Medicinal Chemistry · 2011 · 602 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

An Extremely Potent Inhibitor of Xanthine Oxidoreductase

Ken Okamoto, B.T. Eger, Tomoko Nishino et al. · Journal of Biological Chemistry · 2003 · 424 citations · Full text

Life Sciences, Biochemistry, Pharmacology +8

Possible Role of Liver Cytosolic and Mitochondrial Aldehyde Dehydrogenases in Acetaldehyde Metabolism

Anatole A. Klyosov, Leonid G. Rashkovetsky, M.K. Tahir et al. · Biochemistry · 1996 · 209 citations

Life Sciences, Biochemistry, Pharmacology +17

POTENT INHIBITION OF HUMAN LIVER ALDEHYDE OXIDASE BY RALOXIFENE

R. Scott Obach · Drug Metabolism and Disposition · 2004 · 165 citations

Medicine, Medicinal Chemistry, Pharmacology +11