Inhibition of G Protein-Coupled P2Y₂Receptor Induced Analgesia in a Rat Model of Trigeminal Neuropathic Pain

Abstract

Our data suggest that inhibition of P2Y₂ receptors leads to down-regulation of ERK-mediated phosphorylation and increase of the expression of I(A)-related Kv channels in trigeminal ganglion neurons, which might contribute to the clinical treatment of trigeminal neuropathic pain.