Herbal medicine Yin Zhi Huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

S.M. de Morais, G. Wilkinson, Joyce Blaisdell et al. · Journal of Biological Chemistry · 1994 · 952 citations · Full text

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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of<i>CYP3A4</i>by Rifampicin through a Distal Enhancer Module

Bryan Goodwin, Ecushla Hodgson, Christopher Liddle · Molecular Pharmacology · 1999 · 643 citations

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Inhibition of Human Cytochrome P450 Enzymes by Constituents of St. John's Wort, an Herbal Preparation Used in the Treatment of Depression

R. Scott Obach · Journal of Pharmacology and Experimental Therapeutics · 2000 · 400 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Hepatic CYP2B6 Expression: Gender and Ethnic Differences and Relationship to CYP2B6 Genotype and CAR (Constitutive Androstane Receptor) Expression

Vishal Lamba, Jatinder K. Lamba, Kazuto Yasuda et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 400 citations

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