Annals of Neurology · 2005 · 340 citations · 52 references
EducationNeurologyNeuroscienceAgingCognitive NeuroscienceLifespan DevelopmentCognitive AgingCognitive DeclineCognitive ImpairmentLater AdulthoodLife Course AgingLife Course DevelopmentBrain OrganizationCognitive-functional RelationshipFunctional Capacity DeclineFunctional Impairment SeverityFunctional Reserve DeclineHomeostatic ReserveLife Course EffectsNeurocognitive Decline
The concept of reserve in neuroscience maintains that there are aspects of brain structure and function that can buffer the effects of neuropathology such that the greater the reserve, the more severe the pathology must be to cause functional impairment. This article provides a concise overview of structural and functional approaches to reserve and shows how reserve may be conceived as the sum of its lifetime input. In this context, reserve therefore provides an empirical yet general model of cognitive aging and development.
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