The Mastocytosis Syndrome: Clinical and Biological Studies

Abstract

Article1 August 1963The Mastocytosis Syndrome: Clinical and Biological StudiesD. JOSEPH DEMIS, PH.D., M.D.D. JOSEPH DEMIS, PH.D., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-2-194 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMastocytosis, an abnormal proliferation of tissue mast cells, is being recognized with increasing frequency as a systemic disease. This disorder was originally described by Nettleship in 1869 (1) as its cutaneous manifestation, urticaria pigmentosa. It was not until 1949 that Ellis (2) reported autopsy findings which conclusively demonstrated generalized systemic involvement with infiltration of skin, liver, spleen, bone marrow, lymph nodes, pancreas, and thymus. In the past decade, reports of symptoms associated with the typical clinical eruption have been steadily accumulating (3).Over the past 4 years, 31 patients with mastocytosis have been evaluated. Of these, 12 were noted to...References1. NETTLESHIP E: Rare forms of urticaria. Brit. Med. J. 2: 323, 1869. MedlineGoogle Scholar2. ELLIS JM: Urticaria pigmentosa: Report of a case with autopsy. Arch. Path. 48: 426, 1949. MedlineGoogle Scholar3. DEMISWALTONHIGDON DJMDRS: Histaminuria in urticaria pigmentosa and the mastocytosis syndrome: A clinical study and review of the recent literature with definition of the mastocytosis syndrome. Arch. Derm. (Chicago) 83: 127, 1961. CrossrefMedlineGoogle Scholar4. GROSS P: Urticaria pigmentosa (solitary lesion). Arch. Derm. Syph. 29: 451, 1934. Google Scholar5. SAGHERSCHORR FS: Bone lesions in urticaria pigmentosa. J. Invest. Derm. 26: 431, 1956. CrossrefMedlineGoogle Scholar6. LEESSTROUD MHCE: Bone lesions of urticaria pigmentosa in childhood. Arch. 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CAMPBELLGOWENLOCKPLATTSNOW ACAHDSPJ: A 5-hydroxytryptophan-secreting carcinoid tumor. Gut 4: 61, 1963. CrossrefMedlineGoogle Scholar60. SJOERDSMAOATESZALTZMANUDENFRIEND AJAPS: Serotonin synthesis in carcinoid patients: its inhibition by α-methyl-dopa, with measurement of associated increased in urinary 5-hydroxytryptophan. New Eng. J. Med. 263: 585, 1960. CrossrefMedlineGoogle Scholar61. DEMISZIMMER DJJG: Histaminuria in mastocytosis; the effect of alpha methyl-dopa on urinary excretion of free histamine. Arch. Intern. Med. (Chicago) 111: 309, 1963. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.From the Department of Dermatology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington 12, D. C.Presented at the Forty-third Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 9-13, 1962.Requests for reprints should be addressed to D. Joseph Demis, Ph.D., M.D., Chief, Department of Dermatology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington 12, D. C. 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THOMPSON, M.D., F.A.C.P.MASTOCYTOSIS TREATED WITH L-HYOSCYAMINE (EGAZIL®)Chronic urticariaCaseUrticaria as a Sign of Internal DiseaseBiologically active substances of the mast cellSome studies on the fluorescence of mast cells after paraformaldehyde treatmentSYNTHESIS, UPTAKE AND BINDING OF HISTAMINE AND 5-HYDROXYTRYPTAMINE IN MAST CELLSSolitary mast cell granuloma (histiocytoma) of the lung.A Histopathologic, Tissue Culture and Time-Lapse Cinematographic StudyPerspectives in DermatopathologySome Disorders of Amino Acid Metabolism in Man"Abnormal Metabolites" of Amino Acid OriginMastocytosis Manifested by HepatosplenomegalyClinical, Cytologic, and Biochemical Studies in Systemic Mast Cell DiseaseJ. E. ULTMANN, M.D., F.A.C.P., R. D. MUTTER, M.D., M. TANNENBAUM, M.D., R. R. P. WARNER, M.D., F.A.C.P. 1 August 1963Volume 59, Issue 2Page: 194-206KeywordsExcretionLymph nodesMast cellsMastocytosisPancreasSpleenSystemic diseasesTachycardiaThymusUrticaria Issue Published: 1 August 1963 PDF downloadLoading ...