Switching on a Signaling Pathway with an Organoruthenium Complex

Abstract

Like an organic molecule! A chemically inert ruthenium complex acts as a metallopharmaceutic inhibitor of the protein kinase GSK-3 by targeting its ATP-binding site. It is shown to switch on the Wnt signal transduction pathway inside living cells and in Xenopus embryos, which developed a hyperdorsalized phenotype (see picture, top; bottom: control specimen) on administration of the complex. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462501_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.