OPT-80 Eliminates <i>Clostridium difficile</i> and Is Sparing of <i>Bacteroides</i> Species during Treatment of <i>C. difficile</i> Infection

Abstract

During a 10-day treatment for Clostridium difficile infection, OPT-80 and vancomycin were comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was markedly suppressive. Retention of components of the normal microflora might lower the risk of recurrent disease.