Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception

A potent and selective endogenous agonist for the µ-opiate receptor

James E. Zadina, Laszlo Hackler, Lin-Jun Ge et al. · Nature · 1997 · 1.3K citations

Medicine, Medicinal Chemistry, Pharmacology +12

Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF

Ji‐Sheng Han, X-H Chen, Shengjun Sun et al. · Pain · 1991 · 454 citations

Medicine, Neuroscience, Pharmacology +17

Multiple opioid receptors: ligand selectivity profiles and binding site signatures.

A Goldstein, A Naidu · Molecular Pharmacology · 1989 · 447 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Lumbar catheterization of the spinal subarachnoid space in the rat

Rolf Størkson, Anne Kjørsvik, Arne Tjølsen et al. · Journal of Neuroscience Methods · 1996 · 365 citations

Medicine, Neurological Surgery, Neurosurgery +14

Analgesia induced by electroacupuncture of different frequencies is mediated by different types of opioid receptors: another cross-tolerance study

Xiaohong Chen, Ji-Sheng Han · Behavioural Brain Research · 1992 · 195 citations

Medicine, Anesthesiology, Pharmacology +15