Statistics in Medicine · 1992 · 96 citations · 10 references
Public HealthBiostatisticsDose-response ModelingMeta-analysisOutcomes ResearchBaseline AnalysisBaseline AssessmentBaseline MeasurementClinical TrialsCovariate AdjustmentResponse AssessmentBaseline Covariate AdjustmentBaseline Effect ModelingBaseline-corrected Area Under The CurvePercentage Change AnalysisRandomized Controlled Trial BaselineVariable Data Analysis
Clinical trials data often include baseline and response measurements on each patient. Comparisons of treatments commonly employ either change from baseline or percentage change from baseline as the analysis variable. This paper provides guidance on the choice between these two by means of plots of these variables versus baseline. I provide two examples that illustrate the problem and I discuss the impact of use of the wrong adjusted response.
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