p38 MAP kinase regulates TNFα‐, IL‐1α‐ and PAF‐induced RANTES and GM‐CSF production by human bronchial epithelial cells

Abstract

These results indicate that p38 MAP kinase plays an important role in TNF alpha-, IL-1 alpha- or PAF-activated signalling pathway which regulates RANTES and GM-CSF production by BECs and that the specific inhibitor for p38 MAP kinase activity might be useful for the treatment of allergic inflammation of the airway.