Prevention and reversal of nephritis in MRL/<i>lpr</i> mice with a single injection of C‐reactive protein

Abstract

These findings demonstrate that systemic suppression of autoimmunity is initiated by a single injection of CRP. Long-term maintenance of CRP-mediated protection was reversed by injection of an anti-CD25 monoclonal antibody but not by macrophage depletion, suggesting that disease suppression is maintained by CD25-bearing T cells.