Química Nova · 2011 · 97 citations · 0 references
PharmacyPharmaceutical AnalysisPharmaceuticsColloid ScienceNanomaterialsPharmaceutical FormulationDrug EncapsulationEmulsion FormulationNanoparticle CharacterizationNanoparticle DispersionsNanoparticle FormulationsNanoparticle StabilityEmulsion Stability During StorageEmulsion-based Delivery SystemsEmulsion-based Nanoparticle FormulationNanoemulsion SystemsNanoemulsionsPolydispersity Index AnalysisStorageZeta Potential Measurement
The goal of this study was to evaluate the feasibility of preparing nanocapsules and nanoemulsions using tea tree oil as oily phase aiming to protect its volatilization. The nanostructures presented nanometric mean size (160-220 nm) with a polydispersity index below 0.25 and negative zeta potential. The pH values were 6.43 ± 0.37 and 5.98 ± 0.00 for nanoemulsions and nanocapsules, respectively. The oil content after preparation was 96%. The inclusion of tea tree oil in nanocapsules showed higher protection against volatilization. The analysis of mean size and polydispersity index of formulations presented no significant alteration during the storage time.