Infection and Immunity · 2005 · 72 citations · 23 references
Life SciencesInfectious DiseasesMicrobiologyCytoskeletonHost-pathogen InteractionsMicrobial PathogenesisCell DisruptionIntestinal Barrier FunctionMicrotubule-associated ProteinsMicrotubule-based TransportMucosal PathogenesisToxin-mediated PathogenesisGastrointestinal Barrier DysfunctionIntestinal Mucosal PathogenesisIntestinal PathogenesisMicrotubule Network OrganizationMicrotubule SystemsPathogenesis Of Enteric InfectionsPathogenic Mechanisms Of EnterotoxinsSecreted Effector Proteins
Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules.
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Stuart Knutton, Thomas J. Baldwin, P. H. Williams et al. · Infection and Immunity · 1989 · 884 citations · Full text