A New Unstable and Low Oxygen Affinity Hemoglobin Variant: HB Stanmore [B111 (G13)VAL→ALA]

Abstract

Hb Stanmore is a new hemoglobin variant with the amino acid substitution beta 111(G13)Val----Ala. It is unstable and has a low oxygen affinity. The propositus (of Italian nationality) is a double-heterozygote for Hb Stanmore and beta(0)-thalassemia.