GLUCAGON ANTIBODIES AND AN IMMUNOASSAY FOR GLUCAGON*

Abstract

Despite extensive knowledge of the amino acid composition of beef-pork glucagon, and of the physiologic changes induced by its administration to animals and man, the role of glucagon in the homeostatic regulation of blood glucose level in normal and abnormal states remains to be defined. This fundamental gap in knowledge is the result of the lack of a method sufficiently specific and sensitive to measure endogenous glucagon in body fluids.