Antimicrobial Agents and Chemotherapy · 1990 · 36 citations · 12 references
Veterinary MedicineInfectious DiseasesPharmacologyAntimicrobial PharmacotherapyMedical MicrobiologySepsisAntibiotic ResistanceAntimicrobial TherapySepsis PathophysiologyEnterococcal Infection TreatmentEnterococcal InfectionsPeritoneal Fluid AnalysisTrimethoprim-sulfamethoxazole Therapy
Lethal enterococcal peritonitis in mice was used to compare trimethoprim-sulfamethoxazole (TMP-SMX) therapy with ampicillin therapy. Peritoneal fluid showed a 10(3)-CFU decrease in enterococci with ampicillin compared with TMP-SMX. Mortality of the untreated mice was 100%, compared with 40% for ampicillin and 95% for TMP-SMX, despite adequately measured levels in serum and peritoneal fluid.
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