Design and implementation of a high-throughput biological sample processing facility using modern manufacturing principles

Abstract

BACKGROUND: UK Biobank is a prospective study that is collecting biological samples and health and lifestyle data from 500 000 volunteer participants over a 4-year period. These data will be used to facilitate biological and medical research. METHODS: Modern manufacturing principles were used to direct the development of the sample processing facility and automated systems. RESULTS: A fit for purpose facility comprising technology, systems, dedicated process, infrastructure and an appropriate staff structure has been implemented that will deliver and maintain a resource that will support the long-term goals of the UK Biobank study. CONCLUSIONS: Modern manufacturing principles are appropriate for use in the development of a high throughput biological sample processing facility.