Eine neuartige Fragmentierung bicyclischer Enoläther Verfahren zur Darstellung macrocyclischer Lactone

Abstract

Abstract Vicinal α‐hydroperoxy‐tetrahydropyranyl ethers annelated to cyclododecane are smoothly converted by homolytic fission in about 75% yield to a mixture of the macrocyclic lactones 3 , 4 , and 5. Based on this observation, an economically feasible synthesis of Exaltolide 1 (>65% yield) has been developed. The mechanism of this new β‐fragmentation reaction is discussed.