Cytotoxicity of Gold(I) N‐Heterocyclic Carbene Complexes Assessed by Using Human Tumor Cell Lines

Abstract

Antitumor AuI–NHC: Gold(I) N-heterocyclic carbene complexes exhibit marked cytotoxicity to human tumor cell lines. The cytotoxicity is dependent on the group bound to the gold–NHC moiety: [Au(OH)(IPr)] (1) and [Au(IPr)Cl] (2) are most effective. There was no difference between the cytotoxic effects on normal prostate or breast epithelial cells compared to tumor cells from the same tissue. The active compounds were more potent than cisplatin. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.