Modulating PNA/DNA Hybridization by Light

Abstract

Turn it on! Hybridization of peptide nucleic acids with DNA can be efficiently manipulated by modifying the PNA with a single azobenzene photoswitch. The effect is remarkably strong in the triplex binding mode and can be exploited for the photocontrol of transcription by T7 RNA polymerase (Pol T7). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.