Concepedia

X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase

Larry R. McLean, Ying Zhang, Nisha Zaidi, Xiping Bi, Rachel Wang, Ram Dharanipragada, John G. Jurcak, Timothy A. Gillespy, Zhicheng Zhao, Kwon Musick,

Bioorganic & Medicinal Chemistry Letters · 2012 · 25 citations · 13 references

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13

A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase

S. Atwell, J.M. Adams, John Badger et al. · Journal of Biological Chemistry · 2004 · 192 citations · Full text

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Attenuation of Immunological Symptoms of Allergic Asthma in Mice Lacking the Tyrosine Kinase ITK

Cynthia Mueller, Avery August · The Journal of Immunology · 2003 · 155 citations · Full text

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Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation

Tai-An Lin, Kim W. McIntyre, Jagabandhu Das et al. · Biochemistry · 2004 · 113 citations · Full text

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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors

Jagabandhu Das, Joseph A. Furch, Chunjian Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 75 citations · Full text

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Crystal Structures of Interleukin-2 Tyrosine Kinase and Their Implications for the Design of Selective Inhibitors

Kieron Brown, Joanna Long, Sarah Vial et al. · Journal of Biological Chemistry · 2004 · 62 citations · Full text

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