Concepedia

3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic Ratio

Yueying Zhen, Ondřej Slanař, Kristopher W. Krausz, Chi Chen, Josef Slavík, Kerry L. McPhail, T. Mark Zabriskie, Frank J. Gonzalez, Jeffrey R. Idle

Drug Metabolism and Disposition · 2006 · 14 citations · 40 references

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References

40

Prediction of Creatinine Clearance from Serum Creatinine

Donald W. Cockcroft, Henry Gault · Nephron · 1976 · 15.3K citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

A. Mahgoub, L. G. Dring, Jeffrey R. Idle et al. · The Lancet · 1977 · 1.2K citations

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Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.

Christoph Sachse, Jürgen Brockmöller, Steffen Bauer et al. · PubMed · 1997 · 979 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

Frank J. Gonzalez, Radek C. Skodat, Shioko Kimura et al. · Nature · 1988 · 715 citations

, , +10

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

Michel Eichelbaum, N. Spannbrucker, Barbara Steincke et al. · European Journal of Clinical Pharmacology · 1979 · 635 citations

, , +5