Concepedia

Mice Heterozygous for Tumor Necrosis Factor-α Converting Enzyme Are Protected From Obesity-Induced Insulin Resistance and Diabetes

Matteo Sérino, Rossella Menghini, Loredana Fiorentino, Roberta Amoruso, Alessandro Mauriello, Davide Lauro, Paolo Sbraccia, Marta Letizia Hribal, Renato Lauro, Massimo Federici

Diabetes · 2007 · 111 citations · 22 references

DOIFull text

Open access

Abstract

Our results suggest that modulation of TACE activity is a new pathway to be investigated for development of agents acting against obesity and its metabolic complications.

References

22

Obesity is associated with macrophage accumulation in adipose tissue

Stuart P. Weisberg, Daniel McCann, Manisha Desai et al. · Journal of Clinical Investigation · 2003 · 8.6K citations · Full text

, , +17

Obesity is associated with macrophage accumulation in adipose tissue

Stuart P. Weisberg, Daniel McCann, Manisha Desai et al. · Journal of Clinical Investigation · 2003 · 8.2K citations · Full text

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Toshimasa Yamauchi, Junji Kamon, Yasuhiko Minokoshi et al. · Nature Medicine · 2002 · 4.2K citations

, , +9

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

K. Teoman Uysal, Sarah M. Wiesbrock, Michael W. Marino et al. · Nature · 1997 · 2.2K citations

, , +14

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

Norikazu Maeda, Iichiro Shimomura, Ken Kishida et al. · Nature Medicine · 2002 · 2.1K citations

, , +7