Concepedia

Cytochrome P450 2B6 Catalyzes the Formation of Pharmacologically Active Sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) Metabolites in Human Liver Microsomes

Soo Kyung Bae, Shan Cao, Kyung‐Ah Seo, Hyunmi Kim, Min‐Jung Kim, Ji‐Hong Shon, Kwang‐Hyeon Liu, Hong-Hao Zhou, Jae‐Gook Shin

Drug Metabolism and Disposition · 2008 · 41 citations · 29 references

DOI

Concepts

References

29

Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations

Kiyoshi Yamaoka, Terumichi Nakagawa, Toyozo Uno · Journal of Pharmacokinetics and Biopharmaceutics · 1978 · 2.1K citations

, , +11

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Thomas Lang, Kathrin Klein, Joachim E. Fischer et al. · Pharmacogenetics · 2001 · 569 citations

, , +17

Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan · Drug Metabolism and Disposition · 2006 · 456 citations

, , +17

Hepatic CYP2B6 Expression: Gender and Ethnic Differences and Relationship to CYP2B6 Genotype and CAR (Constitutive Androstane Receptor) Expression

Vishal Lamba, Jatinder K. Lamba, Kazuto Yasuda et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 400 citations

, , +16

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

Tanja Richter, Thomas E. Mürdter, Georg Heinkele et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 260 citations

, , +17