Concepedia

A Comparison of the Transportability, and Its Role in Cytotoxicity, of Clofarabine, Cladribine, and Fludarabine by Recombinant Human Nucleoside Transporters Produced in Three Model Expression Systems

Karen King, Vijaya L. Damaraju, Mark F. Vickers, Sylvia Y.M. Yao, Thach Lang, Tracey Tackaberry, Delores Mowles, Amy M.L. Ng, James D. Young, Carol E. Cass

Molecular Pharmacology · 2005 · 101 citations · 41 references

DOI

Concepts

References

41

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.

S Seto, C J Carrera, Masaru Kubota et al. · Journal of Clinical Investigation · 1985 · 388 citations · Full text

, , +13

Molecular Identification and Characterization of Novel Human and Mouse Concentrative Na+-Nucleoside Cotransporter Proteins (hCNT3 and mCNT3) Broadly Selective for Purine and Pyrimidine Nucleosides (System cib)

Mabel W.L. Ritzel, Amy M.L. Ng, Sylvia Y.M. Yao et al. · Journal of Biological Chemistry · 2001 · 334 citations · Full text

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Functional Characterization of Novel Human and Mouse Equilibrative Nucleoside Transporters (hENT3 and mENT3) Located in Intracellular Membranes

Stephen A. Baldwin, Sylvia Y.M. Yao, Ralph J. Hyde et al. · Journal of Biological Chemistry · 2005 · 322 citations · Full text

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Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia

Hagop M. Kantarjian, Varsha Gandhi, Jörge E. Cortes et al. · Blood · 2003 · 313 citations · Full text

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