Randomized Trial of Fenretinide to Prevent Second Breast Malignancy in Women With Early Breast Cancer

Abstract

Fenretinide treatment of women with breast cancer for 5 years appears to have no statistically significant effect on the incidence of second breast malignancies overall, although a possible benefit was detected in premenopausal women. These studies, particularly the post hoc analyses, are considered exploratory and need to be confirmed.