GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

Patrick A. Grant, Laura J. Duggan, Jacques Côté et al. · Genes & Development · 1997 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53

Shengyun Fang, Jane P. Jensen, Robert L. Ludwig et al. · Journal of Biological Chemistry · 2000 · 1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

Gretchen Bain · Cell · 1994 · 766 citations

Life Sciences, Immunology, Molecular Biology +15

Regulation of the p300 HAT domain via a novel activation loop

Dongxia Wang, Ling Wang, Marcella Fulco et al. · Nature Structural & Molecular Biology · 2004 · 423 citations

Life Sciences, Biochemistry, Molecular Biology +12

Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo

Ernest Martinez, Vikas B. Palhan, Agneta Tjernberg et al. · Molecular and Cellular Biology · 2001 · 374 citations · Full text

Life Sciences, Genetics, Molecular Biology +17