Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl α-ketoamide derivatives containing pyridine moiety

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

James T. Palmer, David Rasnick, Jeffrey L. Klaus et al. · Journal of Medicinal Chemistry · 1995 · 506 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +6

Isolation and characterization of E-64, a new thiol protease inhibitor.

Kazunori Hanada, Masaharu Tamai, Michio Yamagishi et al. · Agricultural and Biological Chemistry · 1978 · 324 citations · Full text

Life Sciences, Biochemistry, Enzymology +16

LEUPEPTINS, NEW PROTEASE INHIBITORS FROM ACTINOMYCETES

TAKAAKI AOYAGI, TOMIO TAKEUCHI, A Matsuzaki et al. · The Journal of Antibiotics · 1969 · 258 citations · Full text

Life Sciences, Biochemistry, Microbiology +12

Inhibitory Effect of di- and Tripeptidyl Aldehydes on Calpains and Cathepsins

Takashi Sasaki, Motoharu Kishi, Masayuki Saito et al. · Journal of enzyme inhibition · 1990 · 204 citations

Life Sciences, Biochemistry, Pharmacology +16

Effect of Size and Charge on the Passive Diffusion of Peptides Across Caco-2 Cell Monolayers via the Paracellular Pathway

Giovanni M. Pauletti, Franklin W. Okumu, Ronald T. Borchardt · Pharmaceutical Research · 1997 · 176 citations

Natural Sciences, Biochemistry, Biophysics +15