Concepedia

P-Glycoprotein Mediates the Efflux of Quinidine across the Blood-Brain Barrier

Hiroyuki Kusuhara, Hiroshi Suzuki, Tetsuya Terasaki, Atsuyuki Kakee, Michel Lemaire, Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics · 1997 · 143 citations · 27 references

DOI

Concepts

References

27

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

Clifford S. Patlak, Ronald G. Blasberg, Joseph D. Fenstermacher · Journal of Cerebral Blood Flow & Metabolism · 1983 · 3.6K citations · Full text

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A pharmacokinetic analysis program (multi) for microcomputer.

Kiyoshi Yamaoka, Yusuke Tanigawara, Terumichi Nakagawa et al. · Journal of Pharmacobio-Dynamics · 1981 · 2.5K citations · Full text

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

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Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

Victor A. Levin · Journal of Medicinal Chemistry · 1980 · 814 citations

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