Design of β‐Hairpin Peptidomimetics That Inhibit Binding of α‐Helical HIV‐1 Rev Protein to the Rev Response Element RNA

Abstract

Bound to please: Binding of the Rev protein to HIV-1 RRE RNA is essential for virus replication. A strategy for the discovery of Rev-RRE inhibitors, based on the use of protein epitope mimetics, is described. Template-bound β-hairpin peptidomimetics (see picture, orange) are designed that mimic the Rev helical epitope (green). The mimetics bind with high affinity and selectivity to the target RNA, and have potential for development into novel anti-viral drugs. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z702801_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.