Immunoglobulin G3 Antibodies Specific for the 19-Kilodalton Carboxyl-Terminal Fragment of<i>Plasmodium yoelii</i>Merozoite Surface Protein 1 Transfer Protection to Mice Deficient in Fc-γRI Receptors

Abstract

ABSTRACT Merozoite surface protein 1 (MSP-1 19 ) is a leading malaria vaccine candidate. Specific antibodies contribute to immunity; binding to macrophages is believed to represent the main action of malaria antibodies. We show that an MSP-1 19 -specific immunoglobulin G3 (IgG3) monoclonal antibody can passively transfer protection to mice deficient in the α chain of Fc-γRI whose macrophages cannot bind IgG3.