Distinct ACPA fine specificities, formed under the influence of HLA shared epitope alleles, have no effect on radiographic joint damage in rheumatoid arthritis

How to read radiographs according to the Sharp/van der Heijde method.

D. van der Heijde · PubMed · 1999 · 1.2K citations

Medicine, Orthopedic Surgery, Radiology +14

Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA–DRB1 shared epitope for antibodies to citrullinated proteins

T. Huizinga, Christopher I. Amos, Annette H M van der Helm–van Mil et al. · Arthritis & Rheumatism · 2005 · 589 citations

Life Sciences, Clinical Sciences, Immunology +17

The HLA–DRB1 shared epitope alleles are primarily a risk factor for anti–cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis

Annette H M van der Helm–van Mil, K. N. Verpoort, Ferdinand C. Breedveld et al. · Arthritis & Rheumatism · 2006 · 349 citations

Life Sciences, Immunology, Internal Medicine +15

Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis

Diane van der Woude, Solbritt Rantapää‐Dahlqvist, A. Ioan-Facsinay et al. · Annals of the Rheumatic Diseases · 2010 · 318 citations

Life Sciences, Immunology, Internal Medicine +17

High anti-cyclic citrullinated peptide levels and an algorithm of four variables predict radiographic progression in patients with rheumatoid arthritis: results from a 10-year longitudinal study

Silje Watterdal Syversen, Per Ivar Gaarder, Guro Løvik Goll et al. · Annals of the Rheumatic Diseases · 2007 · 315 citations

Life Sciences, Immunology, Autoimmunity +15